„Recommendation 16: CD exclusion diet (plus partial EN) should be considered as an alternative to exclusive EN in pediatric patients with mild to moderate CD to achieve remission. Grade of recommendation B – Strong consensus 100% agreement „. [5]

„Recommendation 17: In adult patients, a CD exclusion diet can be considered with or without EN in mild to moderate active CD. Grade of recommendation 0 – Strong consensus 95% agreement“. [5]

„… paediatric CD patients tolerated the CDED coupled with partial enteral nutrition [PEN] better than EEN, and a larger proportion had sustained clinical remission at Week 12“. [4]

„Die erste randomisierte prospektive Studie zur CDED bei Kindern mit M. Crohn von Levine et al. bestätigte die Vergleichbarkeit einer CDED plus PEN versus einer EEN zur Remissionsinduktion nach 6 Wochen und zeigte sogar einen besseren Remissionserhalt nach 12 Wochen“. [7]

„(Pooled) RCT data regarding the effects of experimental diets such as specific carbohydrate, paleolithic, gluten-free, low fermentable oligo-, di- and monosaccharides and polyols (FODMAP), anti-inflammatory diet, carrageenan-free diet, milk-free diet, low or high red meat diet, vegetarian diet and n-3 PUFA enriched diets on intestinal inflammation or on inducing remission are still lacking or give uncertain results at this time“. [5]

„When asked, patients would have a preference for a solid foodbased dietary induction rather than liquid diet. Until recently, more palatable and sustainable dietary strategies with similar efficacy to EEN were not available. Recently, several more tolerable food-based diets were introduced, including CD-TREAT and the Crohn’s Disease Exclusion Diet [CDED]“. [4]

„One small study compared a diet with ordinary foods (CD-TREAT), replicated from and comparable with exclusive EN in healthy adults, demonstrated similar microbiome changes and decreases gut inflammation and still needs to be studied in patients with active CD“. [5]

„Eine Umstellung der Ernährung mit Reduktion fermentierbarer Kohlenhydrate und Polyole (Prinzip der FODMAP-Diät) führte in einer randomisierten Studie mit Patient*innen mit geringer Aktivität ihrer CED, aber dem Vorliegen einer Reizdarmsymptomatik (definiert nach Rom-III-Kriterien), zu einer signifikant besseren Symptomkontrolle (52 % versus 16 %; p = 0,007), hatte aber keinen Einfluss auf die verbliebene entzündliche Aktivität“. [7]

„Passend dazu resultierte aus einer low FODMAP-Ernährung, die u. a. eine Reduktion von Laktose- und Fruktoseaufnahme beinhaltet, eine Reduktion von gastrointestinalen Symptomen bei Patient*innen mit M. Crohn“. [7]

„(Pooled) RCT data regarding the effects of experimental diets such as specific carbohydrate, paleolithic, gluten-free, low fermentable oligo-, di- and monosaccharides and polyols (FODMAP), anti-inflammatory diet, carrageenan-free diet, milk-free diet, low or high red meat diet, vegetarian diet and n-3 PUFA enriched diets on intestinal inflammation or on inducing remission are still lacking or give uncertain results at this time.“ [5]

„Furthermore, there is evidence demonstrating that the low FODMAP diet has a favorable impact on gastrointestinal symptoms in patients with CD“. [5]